SmartVitiNet is an innovative project that aims to scale up, pilot, and bring to the market a holistic phytosanitary and plant protection system based on the use of unmanned aerial vehicles, new observational platforms, and new ready-to-use sensors. The project also aims to establish a Competence Center for Precision Viticulture. The proposed research will enable synergies between members of the quadruple helix, utilizing their complementary knowledge, experiences and infrastructure in the specific area to achieve innovative results. The sustainability of the undertaking will be ensured thanks to the establishment of the Competence Centre for Precision Viticulture, which aims to upskill sector professionals, create expert networks, facilitate permanent flows of knowledge transfer between academia, innovative SMEs, viticulture professionals, and regional authorities to increase sector competitiveness while enacting EU environmental policies, reducing sector health impact and risks of food pollution. SmartVitiNet addresses several S3 priorities of regions involved and is expected to have significant impacts on regional and EU sectors of Agriculture, Health, Environment, and ICT. The duration of the project is 36 months and it involves participants from Greece, Portugal, Cyprus, and France.